Journal article

Clinical Description and Outcomes of Australian Children With Invasive Group A Streptococcal Disease

Elise Thielemans, Jane Oliver, Alissa McMinn, Ciara Baker, Philip N Britton, Julia Clark, Helen Marshall, Christopher C Blyth, Joshua Francis, Jim Buttery, Pierre R Smeesters, Nigel Crawford, Andrew C Steer

The Pediatric Infectious Disease Journal | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

BACKGROUND: Invasive group A streptococcal disease is a severe infection with a high case fatality rate, estimated to cause more than 150,000 deaths per year worldwide. The clinical presentation of this infection is variable, and early diagnosis can be challenging. There are few data on its short- and longer-term outcomes, especially in children. The aim of this study was to assess the clinical presentation, management and short- and longer-term outcomes of invasive group A streptococcal disease in children in Australia. METHODS: We undertook a prospective surveillance study of children with laboratory-confirmed invasive group A streptococcus disease admitted to 7 sentinel tertiary and quate..

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Funding Acknowledgements

We thank all the children and families included in this study, as well as the research nurses and the laboratory staff at the participating hospitals: A/Prof Andrew Daley and Ms Gena Gonis from the Royal Children's Hospital, Melbourne; Mr Andrew Lawrence from Women's and Children's Hospital, South Australia; Dr Avram Levy and Ms Jacinta Bowman from Perth Children's Hospital; Ms Despina Kotsanas from Monash Health; the Territory Pathology microbiology staff; Elizabeth Clark, Kathryn Monaghan and Narelle George from Pathology Queensland; and the staff members of the Children's Microbiology Department at Westmead. PAEDS Network members past and present include Connell J, Dale R, Deverell M, Dougherty S, Finucane C, Gibson M, Gold M, Heath C, Hickie L, Hutchinson T, Jones C, Jones J, Kent J, Knight H, Kynaston A, Lee D, Lewis G, Low S, Macartney K, Maclean N, McDonald F, McLaren N, McRae J, Murphy J, Nissen M, Orr C, Orr K, Phillips N, Pym M, Quinn J, Rhind L, Roberts A, Robins C, Rost L, Royle J, Snelling T, Talbott C, Tan S, Trinh L, Vidler L, Walker M, West R, Wharton C, Wood N, and Zurynski Y. PAEDS is supported by the Australian Government Department of Health and Departments of Health in participating jurisdictions (Victoria NSW, South Australia, Western Australia and Queensland). E.T. acknowledges funding from the Grant of The Belgian Kids' Fund for Pediatric research. H.M. acknowledges National Health and Medical Research Council (NHMRC) Practitioner Fellowship funding. P.N.B. acknowledges NHMRC Early Career Fellowship funding. C.C.B. acknowledges NHMRC Career Development Fellowship. A.C.S. acknowledges NHMRC Career Development Fellowship and National Heart Foundation Future Fellowship funding.