Journal article

Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies

Amanda Phipps, Elizabeth Alwers, Tabitha Harrison, Barbara Banbury, Hermann Brenner, Peter T Campbell, Jenny Chang-Claude, Daniel Buchanan, Andrew T Chan, Alton B Farris, Jane C Figueiredo, Steven Gallinger, Graham G Giles, Mark Jenkins, Roger L Milne, Polly A Newcomb, Martha L Slattery, Mingyang Song, Shuji Ogino, Syed H Zaidi Show all

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2020

Abstract

BACKGROUND AND AIMS: The heterogeneity among colorectal tumors is probably due to differences in developmental pathways and might associate with patient survival times. We studied the relationship among markers of different subtypes of colorectal tumors and patient survival. METHODS: We pooled data from 7 observational studies, comprising 5010 patients with colorectal cancer. All the studies collected information on microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in KRAS and BRAF in tumors. Tumors with complete marker data were classified as type 1 (MSI-high, CIMP-positive, with pathogenic mutations in BRAF but not KRAS), type 2 (not MSI-high, CIMP-pos..

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Grants

Awarded by Genetics and Epidemiology of Colorectal Cancer Consortium: National Cancer Institute (NCI), National Institutes of Health (NIH), US Department of Health and Human Services


Awarded by NIH/NCI Cancer Center Support Grant


Awarded by NCI, NIH


Awarded by German Research Council


Awarded by German Federal Ministry of Education and Research


Awarded by NIH


Awarded by Australian National Health and Medical Research Council


Awarded by Ontario Familial Colorectal Cancer Registry (OFCCR): NIH


Funding Acknowledgements

Grant support: Genetics and Epidemiology of Colorectal Cancer Consortium: National Cancer Institute (NCI), National Institutes of Health (NIH), US Department of Health and Human Services (U01 CA137088 and R01 CA176272). This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA015704. The Colon Cancer Family Registry (CCFR) Illumina Genome-Wide Association Study was supported by funding from NCI, NIH (grant numbers U01 CA122839, R01 CA143247 to Dr. Graham Casey). The CCFR participant recruitment and collection of data and biospecimens used in this study were supported by NCI, NIH (grant number U01 CA167551). Additional funding toward molecular characterization and analyses included the following grants from NCI, NIH: K05CA152715 (to Polly A. Newcomb) and K07CA172298 (to Amanda I. Phipps). The content of this article does not necessarily reflect the views or policies of NCI or any of the collaborating centers in the CCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government, any cancer registry, or the CCFR. CPS-II: The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study-II (CPS-II) cohort. This study was conducted with institutional review board approval. DACHS: This work was supported by the German Research Council (BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, CH 117/1-1, HO 5117/2-1, HE 5998/2-1, KL 2354/3-1, RO 2270/8-1, and BR 1704/17-1), the Interdisciplinary Research Program of the National Center for Tumor Diseases (NCT), Germany, and the German Federal Ministry of Education and Research (01KH0404, 01ER0814, 01ER0815, 01ER1505A, and 01ER1505B). Diet Activity and Lifestyle Study: NIH (R01 CA48998 to Martha L. Slattery). The Health Professionals Follow-up Study is supported by NIH P01 CA055075, UM1 CA167552, U01 CA167552, R01 CA137178, R01 CA151993, R35CA197735, K07 CA190673, and P50 CA127003; and Nurses' Health Study by NIH (R01 CA137178, P01 CA087969, UM1 CA186107, R01 CA151993, R35 CA197735, K07CA190673, and P50 CA127003). The Melbourne Collaborative Cohort Study (MCCS) recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council grants 209057, 396414, and 1074383, and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. Ontario Familial Colorectal Cancer Registry (OFCCR): NIH, through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); see the preceding CCFR section. Additional funding toward genetic analyses of OFCCR includes the Ontario Research Fund, the Canadian Institutes of Health Research, and the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation. Andrew T. Chan is a Stuart and Suzanne Steele MGH Research Scholar.