Journal article

Association between vitamin D status in early pregnancy and atopy in offspring in a vitamin D deplete cohort

Maeve Smith, Eileen C O'Brien, Goiuri Alberdi, Aisling A Geraghty, Mark Kilbane, Malachi J McKenna, Fionnuala M McAuliffe

Irish Journal of Medical Science | SPRINGER LONDON LTD | Published : 2020

Abstract

BACKGROUND: Vitamin D status may play a role in the development of atopic diseases due to its action on lung development and immune system development and function. AIMS: Our objective was to assess whether 25-hydroxyvitamin D (25OHD) levels in maternal blood in pregnancy were associated with atopy in children. METHODS: We analysed 279 mother-child pairs from the ROLO study conducted in Dublin, Ireland. Serum 25OHD was measured at 13 and 28 weeks of pregnancy. Development of childhood atopy was self-reported by mothers at follow-up appointments at 6 months, 2 years or 5 years. Logistic regression analysis was used to evaluate associations between maternal 25OHD status and development of atop..

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