Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies
Aisling A Geraghty, Karen L Lindsay, Goiuri Alberdi, Fionnuala M McAuliffe, Eileen R Gibney
Nutrition and Metabolic Insights | SAGE PUBLICATIONS LTD | Published : 2015
Pregnancy is a vital time of growth and development during which maternal nutrition significantly influences the future health of both mother and baby. During pregnancy, the fetus experiences a critical period of plasticity. Epigenetics, specifically DNA methylation, plays an important role here. As nutrition is influential for DNA methylation, this review aims to determine if maternal nutrition during pregnancy can modify the offspring's epigenome at birth. Research focuses on micronutrients and methyl donors such as folate and B vitamins. Evidence suggests that maternal nutrition does not largely influence global methylation patterns, particularly in nutrient-replete populations; however, ..View full abstract
Awarded by European Union
Aisling A. Geraghty is funded from the European Unions Seventh Framework Programme (FP7/20072013), project EarlyNutrition, under grant agreement no. 289346. The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.