Journal article

Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions

Jairo Campos de Carvalho, Marcelo Grossi Araujo, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes, Claudio Caetano Alvares, Marcela de Lima Moreira, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Marcio Sobreira Silva Araujo

MICROBIAL PATHOGENESIS | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

Abstract

The aim of this study was to identify phenotypic and functional biomarkers associated with distinct clinical status of leprosy or leprosy reactions. The study included tuberculoid/borderline (BB/BT/T) and lepromatous (BL/L) leprosy poles as well as Type-1 and Type-2 leprosy reactions along with healthy controls (NI). A range of peripheral blood biomarkers of innate (neutrophils - NEU and monocytes - MON) and adaptive immunity (CD4+ and CD8+ T-cells) were evaluated ex vivo and upon in vitro stimuli with M. leprae antigen. Data analysis allowed the selection of NEUTLR4+ (ex vivo) and CD4+IL-10+ (in vitro) as universal biomarkers increased in all leprosy patients and those exhibiting leprosy re..

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