Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions
Jairo Campos de Carvalho, Marcelo Grossi Araujo, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes, Claudio Caetano Alvares, Marcela de Lima Moreira, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Marcio Sobreira Silva Araujo
MICROBIAL PATHOGENESIS | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018
The aim of this study was to identify phenotypic and functional biomarkers associated with distinct clinical status of leprosy or leprosy reactions. The study included tuberculoid/borderline (BB/BT/T) and lepromatous (BL/L) leprosy poles as well as Type-1 and Type-2 leprosy reactions along with healthy controls (NI). A range of peripheral blood biomarkers of innate (neutrophils - NEU and monocytes - MON) and adaptive immunity (CD4+ and CD8+ T-cells) were evaluated ex vivo and upon in vitro stimuli with M. leprae antigen. Data analysis allowed the selection of NEUTLR4+ (ex vivo) and CD4+IL-10+ (in vitro) as universal biomarkers increased in all leprosy patients and those exhibiting leprosy re..View full abstract
This work was supported by FAPEMIG, CNPq and IRR/FIOCRUZ-MG. ATC and OAMF are grateful to CNPq for PQ fellowships. JCC received fellowship from PCRH-FAPEMIG. JGCdR received fellowship from the Brazilian National Postdoctoral Fellowship Program (PNPD/CAPES).