Journal article

Understanding the mechanisms driving the spread of subtype C HIV-1

Matthew J Gartner, Michael Roche, Melissa J Churchill, Paul R Gorry, Jacqueline K Flynn

EBIOMEDICINE | ELSEVIER | Published : 2020

Abstract

Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approximately 50% of infections worldwide. C-HIV is the predominant and near-exclusive subtype in the low resource regions of India and Southern Africa. Given the vast diversity of HIV-1 subtypes, it is curious as to why C-HIV constitutes such a large proportion of global infections. This enriched prevalence may be due to phenotypic differences between C-HIV isolates and other viral strains that permit enhanced transmission efficiency or, pathogenicity, or might due to the socio-demographics of the regions where C-HIV is endemic. Here, we compare the mechanisms of C-HIV ..

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