Matrix exopolysaccharides; the sticky side of biofilm formation
Eve Maunders, Martin Welch
FEMS Microbiology Letters | OXFORD UNIV PRESS | Published : 2017
The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously within the environment and is recognised as an opportunistic human pathogen that commonly infects burn wounds and immunocompromised individuals, or patients suffering from the autosomal recessive disorder cystic fibrosis (CF). During chronic infection, P. aeruginosa is thought to form structured aggregates known as biofilms characterised by a self-produced matrix which encases the bacteria, protecting them from antimicrobial attack and the host immune response. In many cases, antibiotics are ineffective at eradicating P. aeruginosa from chronically infected CF airways. Cyclic-di-GMP has been identified as a key regulator..View full abstract
Awarded by Medical Research Council
EM is supported by a Doctoral Training Grant from the MRC. Work in the laboratory of MW is supported by the BBSRC, NC3Rs and the Rosetrees Trust.