Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer.
Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, John Reynolds, Julene Hallo, Orla M McNally, Thomas W Jobling, Andrew N Stephens, Michael A Quinn, Magdalena Plebanski
Scientific Reports | Published : 2020
Pre-operative discrimination of malignant masses is crucial for accurate diagnosis and prompt referral to a gynae oncology centre for optimal surgical intervention. HGSOC progression is correlated with local and systemic inflammation. We hypothesised that inclusion of inflammatory biomarkers in sera may improve diagnostic tests. In the training cohort, we tested four existing clinical tests (RMI score and ROMA, CA125 and HE4) and a panel of 28 immune soluble biomarkers in sera from 66 patients undergoing surgery for suspected ovarian cancer. Six promising immune biomarkers alone, or in combination with conventional tests, were subsequently analysed in an independent validation cohort (n = 69..View full abstract