Conference Proceedings

Towards An Active Micropump-mixer for Rapid Anti-platelet Drug Screening in Whole Blood

Crispin Szydzik, Rose J Brazilek, Farzan Akbaridoust, Charitha de Silva, Mitchell Moon, Ivan Marusic, Harshal H Nandurkar, Justin R Hamilton, Arnan Mitchell, Warwick S Nesbitt, MC Simpson (ed.), S Juodkazis (ed.)

SPIE MICRO + NANO MATERIALS, DEVICES, AND APPLICATIONS 2019 | SPIE-INT SOC OPTICAL ENGINEERING | Published : 2019

Abstract

This work reports on development and characterization of an on-chip microfluidic handling system for application in preclinical anti-platelet drug screening. A reciprocating elastomeric micropump/mixer design is presented for use with whole human blood, utilizing flexible structural and actuation properties to manage hemodynamics for an on-chip platelet thrombosis assay on fibrillar collagen. The hemocompatibility of the design is assessed across a range of operational configurations, demonstrating equivalent or superior performance to common microcapillary systems at a range of physiologically relevant shear conditions. Surprisingly efficient mixing phenomena are briefly investigated, valid..

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