Journal article

The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

Megan Galbally, Stuart J Watson, Marinus van IJzendoorn, Richard Saffery, Joanne Ryan, Edo Ronald de Kloet, Tim F Oberlander, Martha Lappas, Andrew J Lewis

Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

Abstract

Understanding fetal programming pathways that underpin the relationship between maternal and offspring mental health necessitates an exploration of potential role of epigenetic variation in early development. Two genes involved in stress response regulation, the glucocorticoid and mineralocorticoid receptors (NR3C1 and NR3C2) have been a focus in understanding stressful exposures and mental health outcomes. Data were obtained from 236 pregnant women from the Mercy Pregnancy Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort, recruited in early pregnancy. Depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) and repeated measures of the Edinburgh Pos..

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Grants

Awarded by 2012 National Priority Funding Round of Beyond blue in a three-year research grant


Awarded by 2015 National Health and Medical Research Council (NHMRC) project grant for 5 years


Funding Acknowledgements

This study is supported through the 2012 National Priority Funding Round of Beyond blue in a three-year research grant (ID 519240) and a 2015 National Health and Medical Research Council (NHMRC) project grant for 5 years (APP1106823). Financial support has also been obtained from the Academic Research Development Grants from Mercy Health and from the Centre for Mental Health and Well-Being, Deakin University.