Journal article

Abrogation of type-I interferon signalling alters the microglial response to A beta(1-42)

Zachery Moore, Frank Mobilio, Frederick R Walker, Juliet M Taylor, Peter J Crack

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populations associated with type-I IFN signalling, yet how this affects underlying microglial function is yet to be fully elucidated. Here we demonstrate that Aβ1-42 exposure increases bioactive levels of type-I IFN produced by primary microglia alongside increased expression of type-I IFN related genes. Primary microglia isolated from brains of APPswePS1ΔE9 mice with ablated type-I IFN ..

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