Journal article

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac Show all

NATURE | NATURE RESEARCH | Published : 2020

Abstract

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for the regulation of systemic metabolism3,4. Impaired VAT function-for example, in obesity-is associated with insulin resistance and type 2 diabetes5,6. Regulatory T (Treg) cells that express the transcription factor FOXP3 are critical for limiting immune responses and suppressing tissue inflammation, including in the VAT7-9. Here we uncover pronounced sexual dimorphism in Treg cells in the VAT. Male VAT was enriched for Treg cells compared with female VAT, and Treg cells from male VAT were markedly different from their female counterparts in phenotype, transcriptiona..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Diabetes Australia


Awarded by US NIH


Awarded by American Diabetes Association


Funding Acknowledgements

This work was funded by the National Health and Medical Research Council (NHMRC, project grants 1106378 and 1149062 and fellowship 1139607 to A.K.), the Sylvia and Charles Viertel Foundation (fellowship to A.K.), the Diabetes Australia (grant Y18G-VASA to A.V.) and grants from the US NIH (R01DK092541) and JPB Foundation (to D.M.). W.S. is funded by a Walter and Eliza Hall Institute Centenary Fellowship funded by a donation from CSL. M.A.F. is a senior Principal Research Fellow of the NHMRC. P.A.B. was funded by an NBCF Career Development Fellowship. R.G.S. is an American Diabetes Association Postdoctoral fellow (1-17-PMF-005). J.D.Z. and R.A.D. are supported by funding from The Sir Edward Dunlop Medical Research Foundation, The Austin Health Research Foundation and a Les and Eva Erdi Research Grant. R.A.D. was funded by a fellowship from the Australian and New Zealand Bone and Mineral Society. We thank T. Korn for help with experiments, and G. Risbridger, K. S. Korach, M. Ernst, J. Silke and W. C. Boon for mice.