Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion before Thrombectomy in Patients with Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial

BCV Campbell; PJ Mitchell; L Churilov; N Yassi; TJ Kleinig; RJ Dowling; B Yan; SJ Bush; V Thijs; R Scroop; M Simpson; M Brooks; H Asadi; TY Wu; DG Shah; T Wijeratne; H Zhao; F Alemseged; F Ng; P Bailey; H Rice; L De Villiers; HM Dewey; PMC Choi; H Brown; K Redmond; D Leggett; JN Fink; W Collecutt; T Kraemer; M Krause; D Cordato; D Field; H Ma; B O'Brien; B Clissold; F Miteff; A Clissold; GC Cloud; LE Bolitho; L Bonavia; A Bhattacharya; A Wright; A Mamun; F O'Rourke; J Worthington; AA Wong; CR Levi; CF Bladin; G Sharma; PM Desmond; MW Parsons; GA Donnan; SM Davis

Journal article

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion before Thrombectomy in Patients with Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial

BCV Campbell, PJ Mitchell, L Churilov, N Yassi, TJ Kleinig, RJ Dowling, B Yan, SJ Bush, V Thijs, R Scroop, M Simpson, M Brooks, H Asadi, TY Wu, DG Shah, T Wijeratne, H Zhao, F Alemseged, F Ng, P Bailey Show all

JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2020

DOI: 10.1001/jama.2020.1511

Abstract

Importance: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase. Objective: To determine whether 0.40 mg/kg of tenecteplase safely improves reperfusion before endovascular thrombectomy vs 0.25 mg/kg of tenecteplase in patients with large vessel occlusion ischemic stroke. Design, Setting, and Participants: Randomized clinical trial at 27 hospitals in Australia and 1 in New Zealand using open-label treatment and blinded assessment of radiological and clinical outcomes. Patients were enrolled from December 2017 to July 2019 with follow-up until October 2019. Adult patients (N = 300) with ischemic stroke d..

View full abstract

University of Melbourne Researchers

Bruce Campbell Author

Peter Mitchell Author

Leonid Churilov Author

Nawaf Yassi Author

Related Projects (2)

SAVING BRAIN AND CHANGING PRACTICE IN STROKE

Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of ..

OPTIMIZING STROKE THERAPY - ADVANCED BRAIN IMAGING AND REPERFUSION THERAPIES

Most stroke is due to a blocked blood vessel reducing blood flow to the brain. This research aims to optimize fast restoration of blood flow..

Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

EXTEND-IA TNK part 2 was supported by grants from the National Health and Medical Research Council of Australia (1043242, 1035688, 1113352, 1111972) and the National Heart Foundation of Australia (100782). The Victorian government provided infrastructure funding. iSchemaView provided a research version of the RAPID software free of charge for the trial.