Journal article
NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS
RB Delconte, G Guittard, W Goh, S Hediyeh-Zadeh, RJ Hennessy, J Rautela, MJ Davis, F Souza-Fonseca-Guimaraes, JA Nunès, ND Huntington
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2020
Abstract
Natural killer (NK) cell activation is controlled by a balance of activating and inhibitory signals and cytokines such as IL-15. We previously identified cytokine-inducible SH2-containing protein (CIS) as a negative regulator of IL-15 signaling in NK cells under inflammatory conditions. While the functional effect of Cish-deficiency in NK cells was obvious by their increased anti-tumor immunity and hyper-proliferative response to IL-15, it remained unclear how CIS regulates NK cell biology in steady-state. Here, we investigated the role of CIS in the homeostatic maintenance of NK cells and found CIS-ablation promoted terminal differentiation of NK cells and increased turnover, suggesting tha..
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Awarded by Cancer Research Institute
Funding Acknowledgements
This work was supported in Australia by project grants from the National Health and Medical Research Council (NHMRC) of Australia (#1124784, #1066770, #1057852, #1124907 to NH; and #1140406 to FS-F-G). NH was a NHMRC CDF2 Fellow (1124788), a recipient of a Melanoma Research Grant from the Harry J. Lloyd Charitable Trust, Melanoma Research Alliance Young Investigator Award, Ian Potter Foundation equipment grant and a CLIP grant from Cancer Research Institute. RD was a recipient of a Leukemia Foundation PhD scholarship, was supported by a Cancer Council Victoria postdoctoral fellowship and is currently a NHMRC Early Career Fellow (GNT1158615). FS-F-G was supported by a NHMRC Early Career Fellowship (1088703), a National Breast Cancer Foundation (NBCF) Fellowship (PF-15-008), a grant #1120725 awarded through the Priority-driven Collaborative Cancer Research Scheme and funded by Cure Cancer Australia with the assistance of Cancer Australia. GG was supported by a post-doctoral fellowship from the Fondation ARC pour la recherche sur le Cancer and was currently supported by the Janssen Horizon Fonds de dotation. JN's lab was supported by the Groupement des Entreprises Francaises dans la Lutte contre le Cancer GEFLUC) Marseille-Provence.