Haematological features, transfusion management and outcomes of massive obstetric haemorrhage: findings from the Australian and New Zealand Massive Transfusion Registry
Masa Lasica, Rosemary L Sparrow, Mark Tacey, Wendy E Pollock, Erica M Wood, Zoe K McQuilten
British Journal of Haematology | WILEY | Published : 2020
Massive obstetric haemorrhage (MOH) is a leading cause of maternal morbidity and mortality world-wide. Using the Australian and New Zealand Massive Transfusion Registry, we performed a bi-national cohort study of MOH defined as bleeding at ≥20 weeks' gestation or postpartum requiring ≥5 red blood cells (RBC) units within 4 h. Between 2008 and 2015, we identified 249 cases of MOH cases from 19 sites. Predominant causes of MOH were uterine atony (22%), placenta praevia (20%) and obstetric trauma (19%). Intensive care unit admission and/or hysterectomy occurred in 44% and 29% of cases, respectively. There were three deaths. Hypofibrinogenaemia (<2 g/l) occurred in 52% of cases in the first 24 h..View full abstract
The ANZ-MTR has received funding from the National Health and Medical Research Council (Australia), National Blood Authority (Australia), Victorian Government Department of Health and Human Services, Australian Red Cross Blood Service, New Zealand Blood Service, CSL Behring, St John of God Health Care and Monash University.