Journal article

The ubiquitin proteasome system and schizophrenia

Sandra Luza, Carlos M Opazo, Chad A Bousman, Christos Pantelis, Ashley I Bush, Ian P Everall

The Lancet Psychiatry | ELSEVIER SCI LTD | Published : 2020


The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and turnover of scaffolding, presynaptic, and postsynaptic proteins. Moreover, ubiquitin-proteasome system signalling transduces epigenetic changes in neurons independently of protein degradation and, as such, dysfunction of components and substrates of this system has been linked to a broad range of brain conditions. Although links between ubiquitin-proteasome system dysfunction and neurodegenerative disorders have been known for some time, only recently..

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Funding Acknowledgements

The authors acknowledge the financial support of the The Cooperative Research Centre (CRC) for Mental Health. The CRC programme is an Australian Government initiative. CAB was supported by the Alberta Children's Hospital Research Inisititue and Cumming School of Medicine, University of Calgary (Canada). CP was supported by the National Health and Medical Research Council (NHMRC) senior principal research fellowship, a grant from the Lundbeck Foundation, and a NHMRC programme grant. AIB was supported by a NHMRC senior principal research fellowship. None of the funding sources played any role in the writing of this Review or in the decision to submit the manuscript for publication.