Alcohol Use, Mental Health, and Functional Capacity as Predictors of Workplace Disability in a Cohort With Manifest Huntington's Disease
Anita MY Goh, Emily You, Stephanie Perin, Nicola T Lautenschlager, Fiona J Clay, Samantha M Loi, Terence Chong, David Ames, Edmond Chiu, Kathryn A Ellis
The Journal of Neuropsychiatry and Clinical Neurosciences | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2020
OBJECTIVE: Huntington's disease (HD) is an inherited neurodegenerative disease involving motor, cognitive, psychiatric, and behavioral impairments that eventually affect work-role functioning. There is limited research regarding predictors of workplace disability in HD. The authors examined predictors of work impairment and disability in a cross-sectional cohort of employed persons with symptomatic HD participating in the worldwide Enroll-HD study. METHODS: The study sample (N=316) comprised individuals with manifest HD and a CAG repeat length range between 39 and 60 and were currently engaged in paid full- or part-time employment. Univariate and multivariate logistic regression analyses ide..View full abstract
Enroll-HD, a longitudinal observational study for Huntington's disease families intended to accelerate progress toward therapeutics, is sponsored by the Cure Huntington's Disease Initiative Foundation, a nonprofit biomedical research organization exclusively dedicated to developing therapeutics for Huntington's disease.