Alcohol use, mental health, and functional capacity as predictors of workplace disability in a cohort with Manifest Huntington’s disease

Abstract

Objective: Huntington’s disease (HD) is an inherited neu-rodegenerative disease involving motor, cognitive, psychi-atric, and behavioral impairments that eventually affect work-role functioning. There is limited research regarding predictors of workplace disability in HD. The authors examined predictors of work impairment and disability in a cross-sectional cohort of employed persons with symptomatic HD participating in the worldwide Enroll-HD study. Methods: The study sample (N=316) comprised individuals with manifest HD and a CAG repeat length range between 39 and 60 and were currently engaged in paid full-or part-time employment. Univariate and multivariate logistic regression analyses id..