Journal article

Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies

AL Barker, Sze-Ee Soh, Kerrie M Sanders, Julie Pasco, Sundeep Khosla, Peter R Ebeling, Stephanie A Ward, Geeske Peeters, Jason Talevski, Robert G Cumming, Ego Seeman, John J McNeil

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2020

Abstract

OBJECTIVES: This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. METHODS: We conducted a systematic review and exploratory meta-analysis of observational studies. Electronic searches of MEDLINE and Embase, and a manual search of bibliographies was undertaken for studies published to 28 March 2018. Studies were included if: participants were men or women aged ≥18 years; the exposure of interest was aspirin; and relative risks, ORs and 95% CIs for the risk of fracture or difference (percentage or absolute) in BMD (measured by dual energy X-ray absorptiometry) betw..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Career Development Fellowship


Awarded by National Health and Medical Research Council (NHMRC) Postgraduate Scholarship


Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant (project number: APP1067242). ALB was supported by a NHMRC Career Development Fellowship (1067236). JT was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (1151089).