Journal article

Tissue specific regulation of transcription in endometrium and association with disease

Sally Mortlock, Raden I Kendarsari, Jenny N Fung, Greg Gibson, Fei Yang, Restuadi Restuadi, Jane E Girling, Sarah J Holdsworth-Carson, Wan Tinn Teh, Samuel W Lukowski, Martin Healey, Ting Qi, Peter AW Rogers, Jian Yang, Brett McKinnon, Grant W Montgomery

HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2020

Abstract

STUDY QUESTION: Are genetic effects on endometrial gene expression tissue specific and/or associated with reproductive traits and diseases? SUMMARY ANSWER: Analyses of RNA-sequence data and individual genotype data from the endometrium identified novel and disease associated, genetic mechanisms regulating gene expression in the endometrium and showed evidence that these mechanisms are shared across biologically similar tissues. WHAT IS KNOWN ALREADY: The endometrium is a complex tissue vital for female reproduction and is a hypothesized source of cells initiating endometriosis. Understanding genetic regulation specific to, and shared between, tissue types can aid the identification of genes ..

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