Journal article
Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors
NML Amorim, A Kee, ACF Coster, C Lucas, S Bould, S Daniel, JM Weir, NA Mellett, J Barbour, PJ Meikle, RJ Cohn, N Turner, EC Hardeman, D Simar
Metabolism Clinical and Experimental | Published : 2020
Abstract
Background: Metabolic complications are highly prevalent in cancer survivors treated with irradiation but the underlying mechanisms remain unknown. Methods: Chow or high fat-fed C57Bl/6J mice were irradiated (6Gy) before investigating the impact on whole-body or skeletal muscle metabolism and profiling their lipidomic signature. Using a transgenic mouse model (Tg:Pax7-nGFP), we isolated muscle progenitor cells (satellite cells) and characterised their metabolic functions. We recruited childhood cancer survivors, grouped them based on the use of total body irradiation during their treatment and established their lipidomic profile. Results: In mice, irradiation delayed body weight gain and imp..
View full abstractGrants
Awarded by Cancer Council NSW
Funding Acknowledgements
This work was supported by a grant from the Cancer Council New South Wales, Australia (RG 13-17) to E.C.H., D.S. and R.J.C., a grant from the Cancer Institute New South Wales, Australia (RG093633) to R.J.C. and D.S., an International Scholarship from the Brazilian Government (CAPES, process 10448/13-6) to N.M.L.A. and an International Postgraduate Research Scholarship from UNSW Sydney, Australia to S.D.