Journal article

Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a

Jacob T Jackson, Kristy O'Donnell, Amanda Light, Wilford Goh, Nicholas D Huntington, David M Tarlinton, Matthew P McCormack

European Journal of Immunology | WILEY | Published : 2020

Abstract

The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenance. Hhex mediates its effects on HSCs and acute myeloid leukemia stem cells via repression of the Cdkn2a tumor suppressor locus. However, we report here that loss of Cdkn2a does not rescue the failure of lymphoid development caused by loss of Hhex. As loss of Hhex causes apoptosis of lymphoid progenitors associated with impaired Bcl2 expression and defective Stat5b signaling, we..

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