Journal article

Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome

Marco Armando, Mariasole Ciampoli, Maria Carmela Padula, Paul Amminger, Franco De Crescenzo, Johanna Maeder, Maude Schneider, Marie Schaer, Francesca Manago, Stephan Eliez, Francesco Papaleo

Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

Abstract

Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgD..

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Grants

Awarded by Brain and Behavior Research Foundation


Awarded by Compagnia di San Paolo


Awarded by Swiss National Science Foundation


Awarded by National Center of Competence in Research (NCCR) Synapsy-The Synaptic Bases of Mental Diseases


Funding Acknowledgements

This work was supported by funding from the FP Group: the Istituto Italiano di Tecnologia, the Brain and Behavior Research Foundation (2015 NARSAD n. 23234), and the Compagnia di San Paolo (n. 2015-0321); and from the SE Group: the Swiss National Science Foundation (n. FNS 324730_144260), the National Center of Competence in Research (NCCR) Synapsy-The Synaptic Bases of Mental Diseases (n. 51NF40-158776), and the Brain and Behavior Research Foundation (to MA, NARSAD n. 21278).