Journal article

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

Renee M Van der Sluis, Jennifer M Zerbato, Jake W Rhodes, Rachel D Pascoe, Ajantha Solomon, Nitasha A Kumar, Ashanti I Dantanarayana, Surekha Tennakoon, Jeremy Dufloo, James McMahon, Judy J Chang, Vanessa A Evans, Paul J Hertzog, Martin R Jakobsen, Andrew N Harman, Sharon R Lewin, Paul U Cameron

PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells. Latently infected CD4+ T cells do not express viral proteins and are therefore not visible to immune mediated clearance. Therefore, identifying interventions that can reverse latency and also enhance immune mediated clearance is of high interest. Interferons (IFNs) have multiple immune enhancing effects and can inhibit HIV replication in activated CD4+ T cells. However, the effects of IFNs on the establishment and reversal of HIV latency is not understood. Using an in vitro mod..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by European Union


Awarded by AIAS-COFUND II (Marie Curie)


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grant 1041795 and 3162044, S.R.L. is an NHMRC practitioner fellow, R.M.S is a AIAS-COFUND II (Marie Curie) Junior Fellow (grant no A7873), the scheme is funded by the European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie actions (grant agreement no 754513) and Aarhus University Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript