Journal article
Slim electrodes for improved targeting in deep brain stimulation
J Villalobos, HJ McDermott, P McNeill, A Golod, V Rathi, SH Bauquier, JB Fallon
Journal of Neural Engineering | IOP PUBLISHING LTD | Published : 2020
Abstract
Objective. The efficacy of deep brain stimulation can be limited by factors including poor selectivity of stimulation, targeting error, and complications related to implant reliability and stability. We aimed to improve surgical outcomes by evaluating electrode leads with smaller diameter electrode and microelectrodes incorporated which can be used for assisting targeting. Approach. Electrode arrays were constructed with two different diameters of 0.65 mm and the standard 1.3 mm. Micro-electrodes were incorporated into the slim electrode arrays for recording spiking neural activity. Arrays were bilaterally implanted into the medial geniculate body (MGB) in nine anaesthetised cats for 24-40 h..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
We thank Robert K Shepherd and Chris Williams for their contributions to implant development and study design; Laura Didier for her contribution to histological analysis; Lisa Cardamone, Catherine Gaunt and Nicole Critch for assistance during experiments; Ceara McGowan for histological assistance; Rachel Allison and Olivier Bibari for contributions to implant manufacturing; and Sue Pierce and Joy Parker for animal care. This work was supported by the Colonial Foundation and the Australian National Health and Medical Research Council project grant #1113680. The Bionics Institute acknowledges the support received from the Victorian Government through its Operational Infrastructure Support Program.