Journal article

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Devy Deliyanti, Saeed F Alrashdi, Rhian M Touyz, Christopher R Kennedy, Jay C Jha, Mark E Cooper, Karin A Jandeleit-Dahm, Jennifer L Wilkinson-Berka

Hypertension | American Heart Association | Published : 2020

Abstract

Hypertension is a risk factor for the vascular permeability and neovascularization that threatens vision in diabetic retinopathy. Excess reactive oxygen species derived from the Nox (NADPH oxidase) isoforms, Nox1 and Nox4, contributes to vasculopathy in diabetic retinopathy; however, if Nox1/4 inhibition is beneficial in hypertensive diabetic retinopathy is unknown. Here, we determined that diabetic spontaneously hypertensive rats had exacerbated retinal vascular permeability and expression of angiogenic and inflammatory factors, compared with normotensive diabetic Wistar Kyoto rats. GKT136901, a specific dual inhibitor of Nox1 and Nox4, prevented these events in diabetic Wistar Kyoto rats a..

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Grants

Awarded by Juvenile Diabetes Research Foundation


Awarded by Ministry of Education of Saudi Arabia


Awarded by National Health and Medical Research of Australia (NHMRC)


Awarded by British Heart Foundation Chair Award


Funding Acknowledgements

This work was supported by a Juvenile Diabetes Research Foundation fellowship to D. Deliyanti (No. 3-PDF-2017-376-A-N), a PhD scholarship from the Ministry of Education of Saudi Arabia to S.F. Alrashdi (No. 1021389984) and a National Health and Medical Research of Australia (NHMRC) Project Grant to J.L. WilkinsonBerka (No. 107844). R.M. Touyz is funded through a British Heart Foundation Chair Award (CH/12/4/29762). M.E. Cooper is a Senior Principal NHMRC Research Fellow and K.A. Jandeleit-Dahm, a Senior NHMRC Research Fellow. GKT136901 was provided by Genkyotex (Basel, Switzerland). This work was presented in part at the Association for Research In Vision and Ophthalmology Meeting in 2017.