Recent advances in the determination of G protein-coupled receptor structures
David M Thal, Ziva Vuckovic, Christopher J Draper-Joyce, Yi-Lynn Liang, Alisa Glukhova, Arthur Christopoulos, Patrick M Sexton
Current Opinion in Structural Biology | CURRENT BIOLOGY LTD | Published : 2018
G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface receptor proteins and are important drug targets for many human diseases. In the last decade, remarkable progress has been made in the determination of atomic structures of GPCRs with over 200 structures from 53 unique receptors having been solved. Technological advances in protein engineering and X-ray crystallography have driven much of the progress to date. However, recent advances in cryo-electron microscopy have facilitated the structural determination of three new structures of active-state GPCRs in complex with heterotrimeric G protein. These advances have led to significant breakthroughs in our understand..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was funded by the National Health and Medical Research Council of Australia (NHMRC) (grant numbers 1055134, 1061044 and 1084246). D.M.T. and A.G. arc Australian Research Council Discovery Early Career Research Fellows, PALS. is a NHMRC Principal Research Fellow and A.C. a NHMRC Senior Principal Research Fellow.