Journal article

Corneal Epithelial "Neuromas": A Case of Mistaken Identity?

Mary Ann Stepp, Sonali Pal-Ghosh, Laura E Downie, Alexis Ceecee Zhang, Holly R Chinnery, Joshua Machet, Nick Di Girolamo



Laser scanning in vivo confocal microscopy is a useful clinical tool to assess the corneal nerves in human and laboratory animals. With this new technology, the use of terms such as "neuromas" and "microneuromas" is becoming popular to describe nerve structures seen in humans. Here, we point out that the sites where stromal nerves enter the corneal epithelium are often hyperreflective and can appear dysmorphic when imaged using in vivo confocal microscopy. Furthermore, we clarify what is known anatomically about how the nerves enter the corneal epithelium from the stroma, and we urge colleagues to differentiate between hyperreflective foci at the corneal stromal-epithelial nerve penetration ..

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Awarded by NIH/NEI

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

Supported by the NIH/NEI EY08512 (M.A.S.); the National Health and Medical Research Council of Australia, APP1101078 and APP1156944 (N.D.), and APP1126540 (H.R.C.); and the Rebecca L. Cooper Medical Foundation (L.E.D.).