Journal article

Abnormalities at three musculoskeletal sites on whole-body positron emission tomography/computed tomography can diagnose polymyalgia rheumatica with high sensitivity and specificity

Claire E Owen, Aurora MT Poon, Victor Yang, Christopher McMaster, Sze Ting, David FL Liew, Jessica L Leung, Andrew M Scott, Russell RC Buchanan

European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2020

Abstract

PURPOSE: To evaluate the sensitivity and specificity of PET/CT findings in PMR and generate a diagnostic algorithm utilizing a minimum number of musculoskeletal sites. METHODS: Steroid-naïve patients with newly diagnosed PMR (2012 EULAR/ACR classification criteria) were prospectively recruited to undergo whole-body 18F-FDG PET/CT. Each PMR case was age- and sex-matched to four PET/CT controls. Control scan indication, diagnosis and medical history were extracted from the clinical record. Qualitative and semi-quantitative scoring (maximum standardized uptake value [SUVmax]) of abnormal 18F-FDG uptake at 21 musculoskeletal sites was undertaken for cases and controls. Results informed the devel..

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Grants

Awarded by NHMRC


Funding Acknowledgements

This work was funded by an unrestricted educational grant from Abbvie. Author CO has received research grants from Arthritis Australia and Austin Medical Research Foundation. Author AS is supported by an NHMRC Senior Practitioner Fellowship (APP1084178).