Journal article

IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.

Ignacio J Ansotegui, Giovanni Melioli, Giorgio Walter Canonica, Luis Caraballo, Elisa Villa, Motohiro Ebisawa, Giovanni Passalacqua, Eleonora Savi, Didier Ebo, R Maximiliano Gómez, Olga Luengo Sánchez, John J Oppenheimer, Erika Jensen-Jarolim, David A Fischer, Tari Haahtela, Martti Antila, Jean J Bousquet, Victoria Cardona, Wen Chin Chiang, Pascal M Demoly Show all

The World Allergy Organization Journal | Published : 2020

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil acti..

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