Journal article

Factors that predict glycaemic response to sodium-glucose linked transporter (SGLT) inhibitors

Amy L Harding, Naiara Bediaga, Anna Galligan, Peter G Colman, Spiros Fourlanos, John M Wentworth

INTERNAL MEDICINE JOURNAL | WILEY | Published : 2021

Abstract

AIM: To determine the clinical and biochemical variables associated with change in HbA1c in patients with type 2 diabetes who start sodium-glucose linked transporter (SGLT) inhibitor therapy. METHODS: We performed a prospective cohort study (ACTRN12616000833460) of 48 adults (30 male, 18 female) with type 2 diabetes who attended a tertiary hospital diabetes clinic. Fasting serum and urine samples, collected during clinic visits prior to and at 1, 12 and 24 weeks after commencing SGLT inhibitor treatment, were analysed for HbA1c, electrolytes, urea, creatinine and glucose. RESULTS: After 12 weeks, SGLT inhibitor therapy was associated with respective median (97% CI) decreases in weight, blood..

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