Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters
Tania Moniz, Chelsea R Bassett, M Ines GS Almeida, Spas D Kolev, Maria Rangel, Raquel BR Mesquita
TALANTA | ELSEVIER | Published : 2020
This article reports on the development and validation of a disposable microfluidic paper-based analytical device (μPAD) for on-hand, in-situ, and cheap Fe(III) determination in natural waters complying with World Health Organization guidelines. The developed μPAD used 3-hydroxy-4-pyridinone (3,4-HPO) as a colour reagent due to its considerably lower toxicity than traditionally used iron analytical reagents. It was selected among a group of hydrophilic 3,4-HPO chelators containing ether-derived chains in their structure which were prepared using green methods. The relatively high water solubility of these chelators improved the detection limit and applicability as μPAD reagents. Under optima..View full abstract
Awarded by National Funds from FCT
T. Moniz thanks for the financial support provided through projects UID/QUI/50006/2013-POCI/01/0145/FEDER/007265 and UID/QUI/50006/2019; PTDC/AGRPRO/3515/2014-POCI-01-0145-FEDER-016599; NORTE-07-0124-FEDER-000066; NORTE-01-0145-FEDER-000024. This work was supported by National Funds from FCT namely through project UID/Multi/50016/2013.