Journal article

Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters

Tania Moniz, Chelsea R Bassett, M Ines GS Almeida, Spas D Kolev, Maria Rangel, Raquel BR Mesquita

TALANTA | ELSEVIER | Published : 2020

Abstract

This article reports on the development and validation of a disposable microfluidic paper-based analytical device (μPAD) for on-hand, in-situ, and cheap Fe(III) determination in natural waters complying with World Health Organization guidelines. The developed μPAD used 3-hydroxy-4-pyridinone (3,4-HPO) as a colour reagent due to its considerably lower toxicity than traditionally used iron analytical reagents. It was selected among a group of hydrophilic 3,4-HPO chelators containing ether-derived chains in their structure which were prepared using green methods. The relatively high water solubility of these chelators improved the detection limit and applicability as μPAD reagents. Under optima..

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Grants

Awarded by National Funds from FCT



Funding Acknowledgements

T. Moniz thanks for the financial support provided through projects UID/QUI/50006/2013-POCI/01/0145/FEDER/007265 and UID/QUI/50006/2019; PTDC/AGRPRO/3515/2014-POCI-01-0145-FEDER-016599; NORTE-07-0124-FEDER-000066; NORTE-01-0145-FEDER-000024. This work was supported by National Funds from FCT namely through project UID/Multi/50016/2013.