Journal article

Genomic characterisation and context of the blaNDM-1 carbapenemase in Escherichia coli ST101

Melinda Ashcroft, Brian Forde, Minh-Duy Phan, Kate Peters, Andrew Henderson, Steven Hancock, Leah Roberts, Rhys White, Rhys White, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, David Paterson, Timothy Walsh, Mark Schembri, Scott Beatson

Cold Spring Harbor Laboratory | Published : 2019


Abstract Carbapenems are last-resort antibiotics; however, the spread of plasmid-encoded carbapenemases such as the New Delhi metallo-β-lactamase 1 (NDM-1) challenges their effectiveness. The rise of NDM-1 has coincided with the emergence of extensively multidrug resistant (MDR) lineages such as Escherichia coli ST101. Here we present a comprehensive genomic analysis of seven E. coli ST101 isolates that carry the bla NDM-1 gene. We determined the complete genomes of two isolates and the draft genomes of five isolates, enabling complete resolution of the plasmid context of bla NDM-1 . Comparisons with thirteen previously published ST101 genomes revealed a monophyletic lineage within the B1 ph..

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