Journal article

Cognitive Behavioral Therapy for Antenatal Depression in a Pilot Randomized Controlled Trial and Effects on Neurobiological, Behavioral and Cognitive Outcomes in Offspring 3-7 Years Postpartum: A Perspective Article on Study Findings, Limitations and Future Aims

Laura S Bleker, Jeannette Milgrom, Alexandra Sexton-Oates, Donna Parker, Tessa J Roseboom, Alan W Gemmill, Christopher J Holt, Richard Saffery, Alan Connelly, Huibert Burger, Susanne R De Rooij

FRONTIERS IN PSYCHIATRY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Purpose of Article: In a previous pilot randomized controlled trial including 54 pregnant women with depression, maternal mood improved after Cognitive Behavioural Therapy (CBT) compared to treatment as usual (TAU), showing medium to large effect sizes. The effect persisted up to 9 months postpartum, with infant outcomes also showing medium to large effects favoring CBT in various child domains. This perspective article summarizes the results of a follow-up that was performed approximately 5 years later in the same cohort, assessing the effects of antenatal Cognitive Behavioural Therapy for depression and anxiety on child buccal cell DNA-methylation, brain morphology, behavior and cognition...

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Grants

Awarded by Brain and Behavior Research Foundation (NARSAD Young Investigator Grant)


Awarded by DynaHealth: Understanding the Dynamic determinants of glucose homeostasis and psychological capacity to promote healthy and active ageing


Funding Acknowledgements

This study was funded by the Brain and Behavior Research Foundation (NARSAD Young Investigator Grant, project 22975). The first author is funded by DynaHealth: Understanding the Dynamic determinants of glucose homeostasis and psychological capacity to promote healthy and active ageing under Grant Agreement no. 633595 (Horizon2020).