Journal article

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8( ) T Cell Receptors

Louise C Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J D'Orsogna, Thi HO Nguyen, Frans HJ Claas, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Nicole A Mifsud

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8+ T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward ..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Dutch Kidney Foundation


Awarded by NHMRC Principal Research Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) Project Grant (1085018) to AP, NM, and TK, by theMargaret Pratt Foundation to NM and TK, and by the Dutch Kidney Foundation (CP09.04) to HH and FC. AP was supported by a NHMRC Principal Research Fellowship (1137739).