Tissue-resident memory T cells in breast cancer control and immunotherapy responses
Ann Byrne, Peter Savas, Sneha Sant, Ran Li, Balaji Virassamy, Stephen J Luen, Paul A Beavis, Laura K Mackay, Paul J Neeson, Sherene Loi
Nature Reviews Clinical Oncology | NATURE PUBLISHING GROUP | Published : 2020
The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable outcomes in patients with breast cancer as well as in those with other solid tumours. T cells make up a considerable proportion of TILs and current evidence suggests that CD8+ T cells are a crucial determinant of favourable clinical outcomes. Studies involving tumour material from numerous solid tumour types, including breast cancer, demonstrate that the CD8+ TILs include a subpopulation of tissue-resident memory T (TRM) cells. This subpopulation has features consistent with those of TRM cells, which have been described as having a role in peripheral immune surveillance and viral immunity in both humans and ..View full abstract
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Awarded by National Breast Cancer Foundation of Australia Fellowship
The work of S.L. is supported by the National Breast Cancer Foundation of Australia and the Breast Cancer Research Foundation (New York, NY, USA). The work of P.A.B. is supported by a National Breast Cancer Foundation of Australia Fellowship (ECF-17-005).