Journal article

Mesenchymal stromal cells mediated delivery of photoactive nanoparticles inhibits osteosarcoma growth in vitro and in a murine in vivo ectopic model

Stefania Lenna, Chiara Bellotti, Serena Duchi, Elisa Martella, Marta Columbaro, Barbara Dozza, Marco Ballestri, Andrea Guerrini, Giovanna Sotgiu, Tommaso Frisoni, Luca Cevolani, Greta Varchi, Mauro Ferrari, Davide Maria Donati, Enrico Lucarelli

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | BMC | Published : 2020

Abstract

BACKGROUND: Osteosarcoma (OS) is an aggressive malignant neoplasm that still suffers from poor prognosis in the case of distal metastases or occurrence of multi-drug resistance. It is therefore crucial to find novel therapeutic options able to go beyond these limitations and improve patients' survival. The objective of this study is to exploit the intrinsic properties of mesenchymal stromal cells (MSCs) to migrate and infiltrate the tumor stroma to specifically deliver therapeutic agents directly to cancer cells. In particular, we aimed to test the efficacy of the photoactivation of MSCs loaded with nanoparticles in vitro and in a murine in vivo ectopic osteosarcoma model. METHODS: AlPcS4@FN..

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