Simulated Flight, Muscle Genetics, and Inflammatory Indicators in Mice
Barbara St Pierre Schneider, Sheniz Moonie, Nadia D Fulkerson, Jennifer Nicholas, Theo Bammler, Joachim G Voss
AVIATION SPACE AND ENVIRONMENTAL MEDICINE | AEROSPACE MEDICAL ASSOC | Published : 2013
INTRODUCTION: Skeletal muscle discomfort commonly occurs during long-distance air travel. Although the effects of high altitude on muscle have been well-studied, the effects of short-term exposure to the altitude at which aircraft cabins are pressurized, 2438 m, have not. The primary aim of this study was to examine global gene expression in the gastrocnemius muscle after simulated flight. Inflammatory indicators were also assessed in the muscle. METHODS: Thirty-five mice were evenly exposed to normobaria or hypobaria (2438 m) for -8-9 h. Microarray and ribonucleic acid (RNA) analyses were performed. Additionally, macrophage and neutrophil presence was examined. RESULTS: Fourteen genes were ..View full abstract
Awarded by Air Force Surgeon General's Office
This research was sponsored by the Air Force Surgeon General's Office under agreement number FA7014-10-2-0001 (to B.S.S.). The authors thank Joyce TSuji for her technical assistance and Kirsten Speck and Jeffrey Kurrus for editing and manuscript preparation.