Cocapture of cognate and bystander antigens can activate autoreactive B cells.
Nicholas SR Sanderson, Maria Zimmermann, Luca Eilinger, Céline Gubser, Nicole Schaeren-Wiemers, Raija LP Lindberg, Stephanie K Dougan, Hidde L Ploegh, Ludwig Kappos, Tobias Derfuss
Proc Natl Acad Sci U S A | Published : 2017
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of the autoimmune response, but the mechanism connecting the infection to the production of MOG antibodies remains a mystery. We reasoned that the ability of B cells to capture cognate antigen from cell membranes, along with small quantities of coexpressed "bystander" antigens, might enable B-cell escape from tolerance. We tested this hypothesis using influenza hemagglutinin as a model viral antigen and transgenic, MOG-specific B cells. Using flow c..View full abstract
Awarded by Swiss National Science Foundation