Journal article
Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years
B Fagerlund, C Pantelis, JRM Jepsen, JM Raghava, E Rostrup, MB Thomas, MO Nielsen, K Bojesen, KG Jensen, M Stentebjerg-Decara, DG Klauber, D Rudå, BH Ebdrup, K Jessen, A Sigvard, K Tangmose, P Jeppesen, CU Correll, A Fink-Jensen, AK Pagsberg Show all
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2021
Abstract
Background The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition. Methods The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criteria..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
PECANS1 and 2 studies were funded by independent grants from the Lundbeck Foundation (R25-A2701; R13-A1349 and R155-2013-16337), and partially financed by the Mental Health Services in the Capital Region of Denmark, the University of Copenhagen; Marie and Krogh Fund (726290); Worzner Foundation, Gangsted Foundation and a Gerhard Lind scholarship (726261). Prof. Pantelis was supported by an NHMRC Senior Principal Research Fellowship (1105825) and by a grant from the Lundbeck Foundation (R246-2016-3237). The TEA trial was funded by the following public and private funds: The National Research Council for Health and Disease Foundation for Health Promotion (271-07-0066); Tryg Foundation (7-09-02020; 7-11-0899; 7-12-0848 and 110905); AP Moller Foundation; Rosalie Petersens Foundation; Stevn and Rindom Foundation; Foundation for the Promotion of Medical Science; The Capital Region Psychiatric Research Foundation; Region of Southern Denmark Research Foundation; Danish Psychiatric Research Educational Fund; Psychiatry Foundation; Foundation of 17-12-1981; Psychiatric Research Foundation Region Zealand; Capital Region Strategic Research Foundation; Knud og Dagny Andresens Foundation; Psychiatric Research Foundation of 1967; The Capital Region Research Foundation; Dr Sofus Carl Emil Friis and Hustru Olga Friis Scholarship; Tomrerhandler Johannes Fogs Foundation; Brdr Hartmanns Foundation; Aase and Ejnar Danielsens Foundation; Jacob Madsen and wife Olga Madsens Foundation; CC Klestrup and wife Scholarship; Lundbeck Foundation Scholarship and Tomrermester Jorgen Holm and wife Elisas Scholarship (48709/pov).