Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years.
Birgitte Fagerlund, Christos Pantelis, Jens Richardt Møllegaard Jepsen, Jayachandra Mitta Raghava, Egill Rostrup, Marie Bjerregaard Thomas, Mette Ødegaard Nielsen, Kirsten Bojesen, Karsten Gjessing Jensen, Marie Stentebjerg-Decara, Dea Gowers Klauber, Ditte Rudå, Bjørn H Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Pia Jeppesen, Christoph U Correll, Anders Fink-Jensen, Anne Katrine Pagsberg Show all
Psychological Medicine | Cambridge University Press (CUP) | Published : 2020
BACKGROUND: The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition. METHODS: The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criter..View full abstract