Journal article

Regional brain volumes, microstructure and neurodevelopment in moderate-late preterm children

Claire E Kelly, Deanne K Thompson, Alicia J Spittle, Jian Chen, Marc L Seal, Peter J Anderson, Lex W Doyle, Jeanie LY Cheong

Archives of Disease in Childhood - Fetal and Neonatal Edition | BMJ PUBLISHING GROUP | Published : 2020


OBJECTIVE: To explore whether regional brain volume and white matter microstructure at term-equivalent age (TEA) are associated with development at 2 years of age in children born moderate-late preterm (MLPT). STUDY DESIGN: A cohort of MLPT infants had brain MRI at approximately TEA (38-44 weeks' postmenstrual age) and had a developmental assessment (Bayley Scales of Infant and Toddler Development and Infant Toddler Social Emotional Assessment) at 2 years' corrected age. Relationships between cortical grey matter and white matter volumes and 2-year developmental outcomes were explored using voxel-based morphometry. Relationships between diffusion tensor measures of white matter microstructur..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported in part by the Australian National Health and Medical Research Council (NHMRC) (Project Grant ID 1028822 and 1024516; Centre of Clinical Research Excellence Grant ID 546519; Centre of Research Excellence Grant ID 1060733; Senior Research Fellowship ID 1081288 to PA; Early Career Fellowship ID 1053787 to JLYC, ID 1053767 to AS, ID 1012236 to DT; Career Development Fellowship ID 1141354 to JLYC, ID 1108714 to AS, ID 1085754 to DT), Murdoch Children's Research Institute Clinical Sciences Theme Grant, the Royal Children's Hospital, the Department of Paediatrics at the University of Melbourne, the Victorian Government Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation.