Journal article

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

Journal of Theoretical Biology | Elsevier BV | Published : 2020


Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistry. Such models require the development of simplified representations of specific processes which capture essential biophysical features but without unnecessarily complexity. Recently there has been renewed interest in thermodynamically-based modelling of cellular processes. Here we present an approach to developing of simplified yet thermodynamically consistent (hence physically plausible) models which can readily be incorporated into large scale biochemical descriptions but which do not require full mechanistic detail of the underlying processes. We illustrate th..

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Awarded by Australian Research Council

Funding Acknowledgements

PJG would like to thank the Melbourne School of Engineering for its support via a Professorial Fellowship. This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). The authors would like to thank an anonymous reviewer for pointing out an error in an early version of the manuscript and suggesting a number of points of clarification.