Journal article
Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease.
Jacqueline A Bayliss, Moyra Lemus, Vanessa V Santos, Minh Deo, John D Elsworth, Zane B Andrews
Journal of Neurochemistry | Wiley | Published : 2016
DOI: 10.1111/jnc.13576
Abstract
The gut hormone ghrelin is widely beneficial in many disease states. However, ghrelin exists in two distinctive isoforms, each with its own metabolic profile. In Parkinson's Disease (PD) acylated ghrelin administration is neuroprotective, however, the role of des-acylated ghrelin remains unknown. In this study, we wanted to identify the relative contribution each isoform plays using the MPTP model of PD. Chronic administration of acylated ghrelin in mice lacking both isoforms of ghrelin (Ghrelin KO) attenuated the MPTP-induced loss on tyrosine hydroxylase (TH) neuronal number and volume and TH protein expression in the nigrostriatal pathway. Moreover, acylated ghrelin reduced the increase in..
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Awarded by NIA NIH HHS
Awarded by NINDS NIH HHS