Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice.
Alex Reichenbach, Mathieu Mequinion, Jacqueline A Bayliss, Sarah H Lockie, Moyra B Lemus, Randall L Mynatt, Romana Stark, Zane B Andrews
Endocrinology | The Endocrine Society | Published : 2018
Behavioral adaptation to periods of varying food availability is crucial for survival, and agouti-related protein (AgRP) neurons have been associated with entrainment to temporal restricted feeding. We have shown that carnitine acetyltransferase (Crat) in AgRP neurons enables metabolic flexibility and appropriate nutrient partitioning. In this study, by restricting food availability to 3 h/d during the light phase, we examined whether Crat is a component of a food-entrainable oscillator (FEO) that helps link behavior to food availability. AgRP Crat knockout (KO) mice consumed less food and regained less body weight but maintained blood glucose levels during the 25-day restricted feeding prot..View full abstract
Awarded by NIGMS NIH HHS
Awarded by NIDDK NIH HHS