Des-Acyl Ghrelin and Ghrelin O-Acyltransferase Regulate Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Response to Acute Stress.
Romana Stark, Vanessa V Santos, Bram Geenen, Agustina Cabral, Tara Dinan, Jacqueline A Bayliss, Sarah H Lockie, Alex Reichenbach, Moyra B Lemus, Mario Perello, Sarah J Spencer, Tamas Kozicz, Zane B Andrews
Endocrinology | The Endocrine Society | Published : 2016
Ghrelin exists in two forms in circulation, acyl ghrelin and des-acyl ghrelin, both of which have distinct and fundamental roles in a variety of physiological functions. Despite this fact, a large proportion of papers simply measure and refer to plasma ghrelin without specifying the acylation status. It is therefore critical to assess and state the acylation status of plasma ghrelin in all studies. In this study we tested the effect of des-acyl ghrelin administration on the hypothalamic-pituitary-adrenal axis and on anxiety-like behavior of mice lacking endogenous ghrelin and in ghrelin-O-acyltransferase (GOAT) knockout (KO) mice that have no endogenous acyl ghrelin and high endogenous des-a..View full abstract