Journal article

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi

Joseph HA Vissers, Lucas G Dent, Colin M House, Shu Kondo, Kieran F Harvey

GENETICS | OXFORD UNIV PRESS INC | Published : 2020

Abstract

The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues, such as cell polarity and adhesion, into an integrated transcriptional response. The central Hippo signaling effector is the transcriptional coactivator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. When it is not activated by Yorkie, Scalloped can act as a repressor of transcription, at least in part due to its interaction with the corepressor protein Tgi. The mechanism by which Tgi represses transcriptio..

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Grants

Awarded by Victorian Cancer Agency early career seed grant


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

We thank V. Corces, D. Pan, N. Tapon, A. Veraksa, the Vienna D. melanogaster RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the Bloomington Drosophila Stock Center, and the Developmental Studies Hybridoma Bank for D. melanogaster stocks, plasmids, and antibodies. We thank I. Hariharan for discussion of unpublished data. We acknowledge the Peter Mac Microscopy and Histology facility and the University of Melbourne Bio21 Mass spectrometry facility. K.F.H. is a National Health and Medical Research Council Senior Research Fellow (APP1078220). J.H.A.V. was supported by a Victorian Cancer Agency early career seed grant (ECSG14026). This research was supported by the National Health and Medical Research Council of Australia (APP1080131).