Journal article

Ramped pulse shapes are more efficient for cochlear implant stimulation in an animal model

Charlotte Amalie Navntoft, Jeremy Marozeau, Tania Rinaldi Barkat

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2020

Abstract

In all commercial cochlear implant (CI) devices, the electric stimulation is performed with a rectangular pulse that generally has two phases of opposite polarity. To date, developing new stimulation strategies has relied on the efficacy of this shape. Here, we investigate the potential of a novel stimulation paradigm that uses biophysically-inspired electrical ramped pulses. Using electrically-evoked auditory brainstem response (eABR) recordings in mice, we found that less charge, but higher current level amplitude, is needed to evoke responses with ramped shapes that are similar in amplitude to responses obtained with rectangular shapes. The most charge-efficient pulse shape had a rising r..

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Grants

Funding Acknowledgements

This work was supported by a grant from the Swiss National Science Foundation (ERC transfer grant to T.R.B.) and William Demant Foundation (partial salary of C.A.N.). The funder did not have additional role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. We would like to thank Pierre Stahl, Oticon Medical, Nice, France, for providing the Animal Stimulation Platform hardware and software and Bob Carlyon for sharing his lowpass filter model. We would also like to thank the electric workshop at the Biozentrum, University of Basel for the CI electrode connectors and Suyash Joshi for providing feedback on the manuscript.