Journal article

Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders

Simon Ducharme, Annemiek Dols, Robert Laforce, Emma Devenney, Fiona Kumfor, Jan van den Stock, Caroline Dallaire-Theroux, Harro Seelaar, Flora Gossink, Everard Vijverberg, Edward Huey, Mathieu Vandenbulcke, Mario Masellis, Calvin Trieu, Chiadi Onyike, Paulo Caramelli, Leonardo Cruz de Souza, Alexander Santillo, Maria Landqvist Waldo, Ramon Landin-Romero Show all

Brain | OXFORD UNIV PRESS | Published : 2020


The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy of neuroimaging in the early disease stages and the absence of molecular biomarkers, and therefore relies predominantly on clinical assessment. BvFTD shows significant symptomatic overlap with non-degenerative primary psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders. To date, ∼50% of patients with bvFTD receive a prior psychiatric diagnosis, and average diagnostic delay is up to 5-6 year..

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University of Melbourne Researchers