Journal article

Ambulatory Oxygen in Fibrotic Interstitial Lung Disease A Pilot, Randomized, Triple-Blinded, Sham-Controlled Trial

Yet H Khor, Anne E Holland, Nicole SL Goh, Belinda R Miller, Ross Vlahos, Steven Bozinovski, Aroub Lahham, Ian Glaspole, Christine F McDonald

Chest | ELSEVIER | Published : 2020

Abstract

BACKGROUND: Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung disease (ILD) and exertional desaturation. Patients often prefer portable oxygen concentrators to oxygen cylinders. This study aimed to examine the feasibility of conducting a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD. RESEARCH QUESTION: Is it feasible to conduct a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD? STUDY DESIGN AND METHODS: In this randomized, triple-blinded, sham-controlled trial, 30 participants with ILD and isolated exertional desaturation to < 90% on 6..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study was funded by research grants from Austin Medical Research Foundation, Boehringer Ingelheim, Institute for Breathing and Sleep, Lung Foundation Australia (Ivan Cash Grant-in-Aid for Idiopathic Pulmonary Fibrosis Research), and Sir Edward Dunlop Medical Research Foundation. Air Liquide Healthcare provided loan portable oxygen concentrators, nasal cannulas and servicing of the concentrators without charge. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Y. H. K. has received research fellowship support from the National Health and Medical Research Council [grant APP1093506].