Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
Ying Li, Lois A Salamonsen, Jonathan Hyett, Fabricio da Silva Costa, Guiying Nie
Sci Rep | Published : 2017
High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, or two HtrA3-expressing alleles with HtrA3+/- males to investigate the role of maternal vs fetal HtrA3 in placentation. Although HtrA3-/- mice were phenotypically normal and fertile, HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. The IUGR caused by maternal HtrA3 deletio..View full abstract